Understanding Osteoporosis | Prolia | Amgen

APPROXIMATELY 1 IN 3 WOMEN AGED >70 YEARS WILL BREAK A BONE DUE TO OSTEOPOROSIS IN HER REMAINING LIFETIME1

Osteoporosis causes more than 8.9 million fractures annually worldwide, of which more than 4.5 million occur in Europe and USA.2 According to studies, the general incidence of fragility fracture in women is higher than the incidence of heart attack, stroke and breast cancer combined.3–5
Clinical image 1
Data on fractures are annual incidence of any osteoporotic fracture in women aged >50 years across the USA; heart attack is the annual estimate of new or recurrent myocardial infarction in women aged >35 years; stroke data is of women of all ages; and breast cancer data is all new in situ and invasive breast cancer cases in women.3–5

WOMEN LOSE BONE MASS AND EXPERIENCE HIGHER INCIDENCE OF FRACTURES AS THEY AGE6,7

Studies show that women lose bone mass as they age, which happens in parallel with an increase in hip and vertebral fracture incidence.6,7
Across the globe, people are living longer, and by 2020 adults >60 years will outnumber the amount of children <5 years for the first time in history. This increase in lifespan has seen an increase in the amount of cases of long-term conditions such as osteoporosis - making this a major public health problem.8
Strategies to improve the quality of life of older people and reduce the incidence of osteoporosis need to be a priority.8

References:
  1. Kanis JA, et al. Osteoporos Int. 2000;11:669–74.
  2. Johnell O and Kanis JA. Osteoporos Int. 2006;17:1726.
  3. Burge R, et al. J Bone Miner Res. 2007;22:465–75.
  4. Roger VL, et al. Circulation. 2012;125:e2–220.
  5. DeSantis C, et al. CA Cancer J Clin. 2011;61:409–18.
  6. Zebaze R, et al. Lancet. 2010;375:1729–36.
  7. Van Staa TP, et al. Bone 2001;29:517–22.
  8. Osteoporosis Australia. Ageing well must be a global priority. Available at: https://www.osteoporosis.org.au/ageing-well-must-be-global-priority.

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