Osteoporosis - Impact on Daily Activities | Amgen


A bone fracture can lead to fatal consequences. Major osteoporotic fractures are associated with a significant increase in mortality, even in patients aged <65 years.3 In fact, as much as 20% of patients die within 1 year of experiencing a hip fracture.1,2,4
Older women greatly value their health and ability to live independently in the community.5 Unfortunately, a hip fracture can be a lasting limitation to even the most basic of daily tasks.4

Data showing how many patients are independent in self-care after suffering from fractures.

Data are from a review of the Baltimore Hip Studies, a program of research prospectively investigating recovery from hip fracture, which included 674 community-residing patients with hip fracture admitted to hospitals in Baltimore, USA between 01 January 1990 and June 15 1991. Patients were aged ≥65 years and followed prospectively for 24 months from the time of hospitalization. All patients in the analyses shown were previously independent in ADL prior to hip fracture. Eight areas of function were measured by personal interview and direct observation at 2, 6, 12, 18, and 24 months: upper and lower extremity physical and instrumental ADLs; gait and balance; social, cognitive, and affective function. Levels of recovery were identified as the point at which the maximal level of recovery had occurred for each aspect of function. Longitudinal data were analyzed using the system of generalized equations. Dependency was defined as the use of human equipment assistance or an inability to perform a task due to health.4
Due to the physical consequences of a hip fracture, many patients do not regain their mobility.6 Only 1 in 4 patients aged ≤80 years may be able to walk outdoors unaided 12 months after a hip fracture and almost 50% of women aged >80 years may be "forced" to relocate from their own/sheltered home.7
Many patients at high risk of fracture are not being identified and treated. Identifying these individuals can support treatment to prevent fractures in the future.2
Click here to find out about common risk factors for osteoporosis and fracture.
The estimated cost of fragility fractures in the EU is approximately €37 billion per year.8,9


Costs are expected to rise to over €75 billion in 2050.9
clinical image 2
Data are derived from a model and literature report estimating the clinical and economic burden of osteoporotic fractures in 27 countries of the European Union (in 2010) – the report was completed prior to the inclusion of Croatia.8

ADL: activity of daily living.
  1. Ström O, et al. Arch Osteoporos. 2011;6:59–155.
  2. Cooper C. Am J Med. 1997;103:S12–7.
  3. Bliuc D, et al. JAMA. 2009;301:513–21.
  4. Magaziner J, et al. J Gerontol A Biol Sci Med Sci. 2000;55:M498–507.
  5. Salkeld G, et al. BMJ. 2000;320:341–6.
  6. Shah MR, et al. J Orthop Trauma. 2001;15:34–9.
  7. Griffin XL, et al. Bone Joint J. 2015;97:372–82.
  8. Hernlund E, et al. Arch Osteoporos. 2013;8:136.
  9. Kanis JA and Johnell O. Osteoporos Int. 2005;16:229–38.


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